Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome.
Identifieur interne : 000639 ( Main/Exploration ); précédent : 000638; suivant : 000640Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome.
Auteurs : Katharina Röltgen [États-Unis] ; Abigail E. Powell [États-Unis] ; Oliver F. Wirz [États-Unis] ; Bryan A. Stevens [États-Unis] ; Catherine A. Hogan [États-Unis] ; Javaria Najeeb [États-Unis] ; Molly Hunter [États-Unis] ; Hannah Wang [États-Unis] ; Malaya K. Sahoo [États-Unis] ; Chunhong Huang [États-Unis] ; Fumiko Yamamoto [États-Unis] ; Monali Manohar [États-Unis] ; Justin Manalac [États-Unis] ; Ana R. Otrelo-Cardoso [États-Unis] ; Tho D. Pham [États-Unis] ; Arjun Rustagi [États-Unis] ; Angela J. Rogers [États-Unis] ; Nigam H. Shah [États-Unis] ; Catherine A. Blish [États-Unis] ; Jennifer R. Cochran [États-Unis] ; Theodore S. Jardetzky [États-Unis] ; James L. Zehnder [États-Unis] ; Taia T. Wang [États-Unis] ; Balasubramanian Narasimhan [États-Unis] ; Saurabh Gombar [États-Unis] ; Robert Tibshirani [États-Unis] ; Kari C. Nadeau [États-Unis] ; Peter S. Kim [États-Unis] ; Benjamin A. Pinsky [États-Unis] ; Scott D. Boyd [États-Unis]Source :
- Science immunology [ 2470-9468 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Anticorps antiviraux (immunologie), Anticorps antiviraux (sang), Anticorps neutralisants (immunologie), Anticorps neutralisants (sang), Femelle (MeSH), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (immunologie), Glycoprotéine de spicule des coronavirus (sang), Humains (MeSH), Indice de gravité de la maladie (MeSH), Mâle (MeSH), Réaction de polymérisation en chaine en temps réel (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Test ELISA (MeSH).
- MESH :
- génétique : Glycoprotéine de spicule des coronavirus.
- immunologie : Anticorps antiviraux, Anticorps neutralisants, Glycoprotéine de spicule des coronavirus.
- sang : Anticorps antiviraux, Anticorps neutralisants, Glycoprotéine de spicule des coronavirus.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Indice de gravité de la maladie, Mâle, Réaction de polymérisation en chaine en temps réel, Sujet âgé, Sujet âgé de 80 ans ou plus, Test ELISA.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Angiotensin-Converting Enzyme 2 (blood), Angiotensin-Converting Enzyme 2 (genetics), Angiotensin-Converting Enzyme 2 (immunology), Antibodies, Neutralizing (blood), Antibodies, Neutralizing (immunology), Antibodies, Viral (blood), Antibodies, Viral (immunology), COVID-19 (blood), COVID-19 (genetics), COVID-19 (immunology), Enzyme-Linked Immunosorbent Assay (MeSH), Female (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Real-Time Polymerase Chain Reaction (MeSH), SARS-CoV-2 (genetics), SARS-CoV-2 (immunology), Severity of Illness Index (MeSH), Spike Glycoprotein, Coronavirus (blood), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology).
- MESH :
- chemical , blood : Angiotensin-Converting Enzyme 2, Antibodies, Neutralizing, Antibodies, Viral, Spike Glycoprotein, Coronavirus.
- chemical , genetics : Angiotensin-Converting Enzyme 2, Spike Glycoprotein, Coronavirus.
- chemical , immunology : Angiotensin-Converting Enzyme 2, Antibodies, Neutralizing, Antibodies, Viral, Spike Glycoprotein, Coronavirus.
- blood : COVID-19.
- genetics : COVID-19, SARS-CoV-2.
- immunology : COVID-19, SARS-CoV-2.
- Adult, Aged, Aged, 80 and over, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Real-Time Polymerase Chain Reaction, Severity of Illness Index.
Abstract
SARS-CoV-2-specific antibodies, particularly those preventing viral spike receptor binding domain (RBD) interaction with host angiotensin-converting enzyme 2 (ACE2) receptor, can neutralize the virus. It is, however, unknown which features of the serological response may affect clinical outcomes of COVID-19 patients. We analyzed 983 longitudinal plasma samples from 79 hospitalized COVID-19 patients and 175 SARS-CoV-2-infected outpatients and asymptomatic individuals. Within this cohort, 25 patients died of their illness. Higher ratios of IgG antibodies targeting S1 or RBD domains of spike compared to nucleocapsid antigen were seen in outpatients who had mild illness versus severely ill patients. Plasma antibody increases correlated with decreases in viral RNAemia, but antibody responses in acute illness were insufficient to predict inpatient outcomes. Pseudovirus neutralization assays and a scalable ELISA measuring antibodies blocking RBD-ACE2 interaction were well correlated with patient IgG titers to RBD. Outpatient and asymptomatic individuals' SARS-CoV-2 antibodies, including IgG, progressively decreased during observation up to five months post-infection.
DOI: 10.1126/sciimmunol.abe0240
PubMed: 33288645
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Cochran</name><affiliation wicri:level="4"><nlm:affiliation>Department of Bioengineering, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Jardetzky, Theodore S" sort="Jardetzky, Theodore S" uniqKey="Jardetzky T" first="Theodore S" last="Jardetzky">Theodore S. Jardetzky</name><affiliation wicri:level="4"><nlm:affiliation>Department of Structural Biology, Stanford University, Stanford, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Structural Biology, Stanford University, Stanford</wicri:regionArea><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Zehnder, James L" sort="Zehnder, James L" uniqKey="Zehnder J" first="James L" last="Zehnder">James L. Zehnder</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Narasimhan, Balasubramanian" sort="Narasimhan, Balasubramanian" uniqKey="Narasimhan B" first="Balasubramanian" last="Narasimhan">Balasubramanian Narasimhan</name><affiliation wicri:level="4"><nlm:affiliation>Department of Statistics, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Statistics, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedical Data Sciences, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Data Sciences, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Gombar, Saurabh" sort="Gombar, Saurabh" uniqKey="Gombar S" first="Saurabh" last="Gombar">Saurabh Gombar</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tibshirani, Robert" sort="Tibshirani, Robert" uniqKey="Tibshirani R" first="Robert" last="Tibshirani">Robert Tibshirani</name><affiliation wicri:level="4"><nlm:affiliation>Department of Statistics, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Statistics, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedical Data Sciences, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Data Sciences, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Nadeau, Kari C" sort="Nadeau, Kari C" uniqKey="Nadeau K" first="Kari C" last="Nadeau">Kari C. Nadeau</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kim, Peter S" sort="Kim, Peter S" uniqKey="Kim P" first="Peter S" last="Kim">Peter S. Kim</name><affiliation wicri:level="2"><nlm:affiliation>Stanford ChEM-H and Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford ChEM-H and Department of Biochemistry, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Pinsky, Benjamin A" sort="Pinsky, Benjamin A" uniqKey="Pinsky B" first="Benjamin A" last="Pinsky">Benjamin A. Pinsky</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. sboyd1@stanford.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33288645</idno><idno type="pmid">33288645</idno><idno type="doi">10.1126/sciimmunol.abe0240</idno><idno type="wicri:Area/Main/Corpus">000118</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000118</idno><idno type="wicri:Area/Main/Curation">000118</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000118</idno><idno type="wicri:Area/Main/Exploration">000118</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome.</title><author><name sortKey="Roltgen, Katharina" sort="Roltgen, Katharina" uniqKey="Roltgen K" first="Katharina" last="Röltgen">Katharina Röltgen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Powell, Abigail E" sort="Powell, Abigail E" uniqKey="Powell A" first="Abigail E" last="Powell">Abigail E. Powell</name><affiliation wicri:level="2"><nlm:affiliation>Stanford ChEM-H and Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford ChEM-H and Department of Biochemistry, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wirz, Oliver F" sort="Wirz, Oliver F" uniqKey="Wirz O" first="Oliver F" last="Wirz">Oliver F. Wirz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Stevens, Bryan A" sort="Stevens, Bryan A" uniqKey="Stevens B" first="Bryan A" last="Stevens">Bryan A. Stevens</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hogan, Catherine A" sort="Hogan, Catherine A" uniqKey="Hogan C" first="Catherine A" last="Hogan">Catherine A. Hogan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Najeeb, Javaria" sort="Najeeb, Javaria" uniqKey="Najeeb J" first="Javaria" last="Najeeb">Javaria Najeeb</name><affiliation wicri:level="4"><nlm:affiliation>Department of Structural Biology, Stanford University, Stanford, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Structural Biology, Stanford University, Stanford</wicri:regionArea><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Hunter, Molly" sort="Hunter, Molly" uniqKey="Hunter M" first="Molly" last="Hunter">Molly Hunter</name><affiliation wicri:level="2"><nlm:affiliation>ATUM, Newark, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>ATUM, Newark, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wang, Hannah" sort="Wang, Hannah" uniqKey="Wang H" first="Hannah" last="Wang">Hannah Wang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sahoo, Malaya K" sort="Sahoo, Malaya K" uniqKey="Sahoo M" first="Malaya K" last="Sahoo">Malaya K. Sahoo</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Huang, Chunhong" sort="Huang, Chunhong" uniqKey="Huang C" first="Chunhong" last="Huang">Chunhong Huang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yamamoto, Fumiko" sort="Yamamoto, Fumiko" uniqKey="Yamamoto F" first="Fumiko" last="Yamamoto">Fumiko Yamamoto</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Manohar, Monali" sort="Manohar, Monali" uniqKey="Manohar M" first="Monali" last="Manohar">Monali Manohar</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Manalac, Justin" sort="Manalac, Justin" uniqKey="Manalac J" first="Justin" last="Manalac">Justin Manalac</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Otrelo Cardoso, Ana R" sort="Otrelo Cardoso, Ana R" uniqKey="Otrelo Cardoso A" first="Ana R" last="Otrelo-Cardoso">Ana R. Otrelo-Cardoso</name><affiliation wicri:level="4"><nlm:affiliation>Department of Structural Biology, Stanford University, Stanford, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Structural Biology, Stanford University, Stanford</wicri:regionArea><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Pham, Tho D" sort="Pham, Tho D" uniqKey="Pham T" first="Tho D" last="Pham">Tho D. Pham</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Stanford Blood Center, Palo Alto, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Blood Center, Palo Alto, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rustagi, Arjun" sort="Rustagi, Arjun" uniqKey="Rustagi A" first="Arjun" last="Rustagi">Arjun Rustagi</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Rogers, Angela J" sort="Rogers, Angela J" uniqKey="Rogers A" first="Angela J" last="Rogers">Angela J. Rogers</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Shah, Nigam H" sort="Shah, Nigam H" uniqKey="Shah N" first="Nigam H" last="Shah">Nigam H. Shah</name><affiliation wicri:level="4"><nlm:affiliation>Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Cochran, Jennifer R" sort="Cochran, Jennifer R" uniqKey="Cochran J" first="Jennifer R" last="Cochran">Jennifer R. Cochran</name><affiliation wicri:level="4"><nlm:affiliation>Department of Bioengineering, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Jardetzky, Theodore S" sort="Jardetzky, Theodore S" uniqKey="Jardetzky T" first="Theodore S" last="Jardetzky">Theodore S. Jardetzky</name><affiliation wicri:level="4"><nlm:affiliation>Department of Structural Biology, Stanford University, Stanford, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Structural Biology, Stanford University, Stanford</wicri:regionArea><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Zehnder, James L" sort="Zehnder, James L" uniqKey="Zehnder J" first="James L" last="Zehnder">James L. Zehnder</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Narasimhan, Balasubramanian" sort="Narasimhan, Balasubramanian" uniqKey="Narasimhan B" first="Balasubramanian" last="Narasimhan">Balasubramanian Narasimhan</name><affiliation wicri:level="4"><nlm:affiliation>Department of Statistics, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Statistics, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedical Data Sciences, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Data Sciences, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Gombar, Saurabh" sort="Gombar, Saurabh" uniqKey="Gombar S" first="Saurabh" last="Gombar">Saurabh Gombar</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tibshirani, Robert" sort="Tibshirani, Robert" uniqKey="Tibshirani R" first="Robert" last="Tibshirani">Robert Tibshirani</name><affiliation wicri:level="4"><nlm:affiliation>Department of Statistics, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Statistics, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedical Data Sciences, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Data Sciences, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Nadeau, Kari C" sort="Nadeau, Kari C" uniqKey="Nadeau K" first="Kari C" last="Nadeau">Kari C. Nadeau</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kim, Peter S" sort="Kim, Peter S" uniqKey="Kim P" first="Peter S" last="Kim">Peter S. Kim</name><affiliation wicri:level="2"><nlm:affiliation>Stanford ChEM-H and Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford ChEM-H and Department of Biochemistry, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Pinsky, Benjamin A" sort="Pinsky, Benjamin A" uniqKey="Pinsky B" first="Benjamin A" last="Pinsky">Benjamin A. Pinsky</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. sboyd1@stanford.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Science immunology</title><idno type="eISSN">2470-9468</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Angiotensin-Converting Enzyme 2 (blood)</term><term>Angiotensin-Converting Enzyme 2 (genetics)</term><term>Angiotensin-Converting Enzyme 2 (immunology)</term><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Neutralizing (immunology)</term><term>Antibodies, Viral (blood)</term><term>Antibodies, Viral (immunology)</term><term>COVID-19 (blood)</term><term>COVID-19 (genetics)</term><term>COVID-19 (immunology)</term><term>Enzyme-Linked Immunosorbent Assay (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Real-Time Polymerase Chain Reaction (MeSH)</term><term>SARS-CoV-2 (genetics)</term><term>SARS-CoV-2 (immunology)</term><term>Severity of Illness Index (MeSH)</term><term>Spike Glycoprotein, Coronavirus (blood)</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Spike Glycoprotein, Coronavirus (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Anticorps antiviraux (immunologie)</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (immunologie)</term><term>Anticorps neutralisants (sang)</term><term>Femelle (MeSH)</term><term>Glycoprotéine de spicule des coronavirus (génétique)</term><term>Glycoprotéine de spicule des coronavirus (immunologie)</term><term>Glycoprotéine de spicule des coronavirus (sang)</term><term>Humains (MeSH)</term><term>Indice de gravité de la maladie (MeSH)</term><term>Mâle (MeSH)</term><term>Réaction de polymérisation en chaine en temps réel (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Test ELISA (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Angiotensin-Converting Enzyme 2</term><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Angiotensin-Converting Enzyme 2</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Angiotensin-Converting Enzyme 2</term><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>COVID-19</term><term>SARS-CoV-2</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine de spicule des coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term><term>Glycoprotéine de spicule des coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>COVID-19</term><term>SARS-CoV-2</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term><term>Glycoprotéine de spicule des coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Real-Time Polymerase Chain Reaction</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Indice de gravité de la maladie</term><term>Mâle</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">SARS-CoV-2-specific antibodies, particularly those preventing viral spike receptor binding domain (RBD) interaction with host angiotensin-converting enzyme 2 (ACE2) receptor, can neutralize the virus. It is, however, unknown which features of the serological response may affect clinical outcomes of COVID-19 patients. We analyzed 983 longitudinal plasma samples from 79 hospitalized COVID-19 patients and 175 SARS-CoV-2-infected outpatients and asymptomatic individuals. Within this cohort, 25 patients died of their illness. Higher ratios of IgG antibodies targeting S1 or RBD domains of spike compared to nucleocapsid antigen were seen in outpatients who had mild illness versus severely ill patients. Plasma antibody increases correlated with decreases in viral RNAemia, but antibody responses in acute illness were insufficient to predict inpatient outcomes. Pseudovirus neutralization assays and a scalable ELISA measuring antibodies blocking RBD-ACE2 interaction were well correlated with patient IgG titers to RBD. Outpatient and asymptomatic individuals' SARS-CoV-2 antibodies, including IgG, progressively decreased during observation up to five months post-infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">33288645</PMID><DateCompleted><Year>2020</Year><Month>12</Month><Day>18</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2470-9468</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>54</Issue><PubDate><Year>2020</Year><Month>12</Month><Day>07</Day></PubDate></JournalIssue><Title>Science immunology</Title><ISOAbbreviation>Sci Immunol</ISOAbbreviation></Journal><ArticleTitle>Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">eabe0240</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1126/sciimmunol.abe0240</ELocationID><Abstract><AbstractText>SARS-CoV-2-specific antibodies, particularly those preventing viral spike receptor binding domain (RBD) interaction with host angiotensin-converting enzyme 2 (ACE2) receptor, can neutralize the virus. It is, however, unknown which features of the serological response may affect clinical outcomes of COVID-19 patients. We analyzed 983 longitudinal plasma samples from 79 hospitalized COVID-19 patients and 175 SARS-CoV-2-infected outpatients and asymptomatic individuals. Within this cohort, 25 patients died of their illness. Higher ratios of IgG antibodies targeting S1 or RBD domains of spike compared to nucleocapsid antigen were seen in outpatients who had mild illness versus severely ill patients. Plasma antibody increases correlated with decreases in viral RNAemia, but antibody responses in acute illness were insufficient to predict inpatient outcomes. Pseudovirus neutralization assays and a scalable ELISA measuring antibodies blocking RBD-ACE2 interaction were well correlated with patient IgG titers to RBD. Outpatient and asymptomatic individuals' SARS-CoV-2 antibodies, including IgG, progressively decreased during observation up to five months post-infection.</AbstractText><CopyrightInformation>Copyright © 2020, American Association for the Advancement of Science.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Röltgen</LastName><ForeName>Katharina</ForeName><Initials>K</Initials><Identifier Source="ORCID">0000-0002-1582-1720</Identifier><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Powell</LastName><ForeName>Abigail E</ForeName><Initials>AE</Initials><Identifier Source="ORCID">0000-0001-6408-9495</Identifier><AffiliationInfo><Affiliation>Stanford ChEM-H and Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Wirz</LastName><ForeName>Oliver F</ForeName><Initials>OF</Initials><Identifier Source="ORCID">0000-0003-0377-6464</Identifier><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Stevens</LastName><ForeName>Bryan A</ForeName><Initials>BA</Initials><Identifier Source="ORCID">0000-0002-1713-3163</Identifier><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hogan</LastName><ForeName>Catherine A</ForeName><Initials>CA</Initials><Identifier Source="ORCID">0000-0003-1977-253X</Identifier><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Najeeb</LastName><ForeName>Javaria</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Structural Biology, Stanford University, Stanford, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hunter</LastName><ForeName>Molly</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>ATUM, Newark, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Hannah</ForeName><Initials>H</Initials><Identifier Source="ORCID">0000-0002-3712-9188</Identifier><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sahoo</LastName><ForeName>Malaya K</ForeName><Initials>MK</Initials><Identifier Source="ORCID">0000-0001-9837-4032</Identifier><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>ChunHong</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yamamoto</LastName><ForeName>Fumiko</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manohar</LastName><ForeName>Monali</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manalac</LastName><ForeName>Justin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Otrelo-Cardoso</LastName><ForeName>Ana R</ForeName><Initials>AR</Initials><Identifier Source="ORCID">0000-0003-2606-9367</Identifier><AffiliationInfo><Affiliation>Department of Structural Biology, Stanford University, Stanford, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pham</LastName><ForeName>Tho D</ForeName><Initials>TD</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Stanford Blood Center, Palo Alto, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rustagi</LastName><ForeName>Arjun</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0002-6921-1012</Identifier><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rogers</LastName><ForeName>Angela J</ForeName><Initials>AJ</Initials><Identifier Source="ORCID">0000-0001-6969-6200</Identifier><AffiliationInfo><Affiliation>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shah</LastName><ForeName>Nigam H</ForeName><Initials>NH</Initials><Identifier Source="ORCID">0000-0001-9385-7158</Identifier><AffiliationInfo><Affiliation>Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blish</LastName><ForeName>Catherine A</ForeName><Initials>CA</Initials><Identifier Source="ORCID">0000-0001-6946-7627</Identifier><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cochran</LastName><ForeName>Jennifer R</ForeName><Initials>JR</Initials><Identifier Source="ORCID">0000-0002-6532-9873</Identifier><AffiliationInfo><Affiliation>Department of Bioengineering, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jardetzky</LastName><ForeName>Theodore S</ForeName><Initials>TS</Initials><Identifier Source="ORCID">0000-0002-3664-0072</Identifier><AffiliationInfo><Affiliation>Department of Structural Biology, Stanford University, Stanford, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zehnder</LastName><ForeName>James L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Taia T</ForeName><Initials>TT</Initials><Identifier Source="ORCID">0000-0002-3894-685X</Identifier><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Narasimhan</LastName><ForeName>Balasubramanian</ForeName><Initials>B</Initials><Identifier Source="ORCID">0000-0001-5852-7639</Identifier><AffiliationInfo><Affiliation>Department of Statistics, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biomedical Data Sciences, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gombar</LastName><ForeName>Saurabh</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tibshirani</LastName><ForeName>Robert</ForeName><Initials>R</Initials><Identifier Source="ORCID">0000-0003-0553-5090</Identifier><AffiliationInfo><Affiliation>Department of Statistics, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biomedical Data Sciences, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nadeau</LastName><ForeName>Kari C</ForeName><Initials>KC</Initials><Identifier Source="ORCID">0000-0002-2146-2955</Identifier><AffiliationInfo><Affiliation>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Kim</LastName><ForeName>Peter S</ForeName><Initials>PS</Initials><Identifier Source="ORCID">0000-0001-6503-4541</Identifier><AffiliationInfo><Affiliation>Stanford ChEM-H and Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Pinsky</LastName><ForeName>Benjamin A</ForeName><Initials>BA</Initials><Identifier Source="ORCID">0000-0001-8751-4810</Identifier><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Boyd</LastName><ForeName>Scott D</ForeName><Initials>SD</Initials><Identifier Source="ORCID">0000-0003-0963-044X</Identifier><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. sboyd1@stanford.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AI127877</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI130398</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>1U54CA260517</GrantID><Acronym>NH</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32AI007502-23</GrantID><Acronym>NH</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U19 AI111825</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR003142</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Sci Immunol</MedlineTA><NlmUniqueID>101688624</NlmUniqueID><ISSNLinking>2470-9468</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D057134">Antibodies, Neutralizing</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C578557">spike glycoprotein, SARS-CoV</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.17.23</RegistryNumber><NameOfSubstance UI="C000705307">ACE2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.17.23</RegistryNumber><NameOfSubstance UI="D000085962">Angiotensin-Converting Enzyme 2</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000085962" MajorTopicYN="N">Angiotensin-Converting Enzyme 2</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057134" MajorTopicYN="N">Antibodies, Neutralizing</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="Y">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>10</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>12</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>12</Month><Day>8</Day><Hour>5</Hour><Minute>39</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>12</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>12</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33288645</ArticleId><ArticleId IdType="pii">5/54/eabe0240</ArticleId><ArticleId IdType="doi">10.1126/sciimmunol.abe0240</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Stanford (Californie)</li></settlement><orgName><li>Université Stanford</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Roltgen, Katharina" sort="Roltgen, Katharina" uniqKey="Roltgen K" first="Katharina" last="Röltgen">Katharina Röltgen</name></region><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name><name sortKey="Cochran, Jennifer R" sort="Cochran, Jennifer R" uniqKey="Cochran J" first="Jennifer R" last="Cochran">Jennifer R. Cochran</name><name sortKey="Gombar, Saurabh" sort="Gombar, Saurabh" uniqKey="Gombar S" first="Saurabh" last="Gombar">Saurabh Gombar</name><name sortKey="Hogan, Catherine A" sort="Hogan, Catherine A" uniqKey="Hogan C" first="Catherine A" last="Hogan">Catherine A. Hogan</name><name sortKey="Huang, Chunhong" sort="Huang, Chunhong" uniqKey="Huang C" first="Chunhong" last="Huang">Chunhong Huang</name><name sortKey="Hunter, Molly" sort="Hunter, Molly" uniqKey="Hunter M" first="Molly" last="Hunter">Molly Hunter</name><name sortKey="Jardetzky, Theodore S" sort="Jardetzky, Theodore S" uniqKey="Jardetzky T" first="Theodore S" last="Jardetzky">Theodore S. Jardetzky</name><name sortKey="Kim, Peter S" sort="Kim, Peter S" uniqKey="Kim P" first="Peter S" last="Kim">Peter S. Kim</name><name sortKey="Kim, Peter S" sort="Kim, Peter S" uniqKey="Kim P" first="Peter S" last="Kim">Peter S. Kim</name><name sortKey="Manalac, Justin" sort="Manalac, Justin" uniqKey="Manalac J" first="Justin" last="Manalac">Justin Manalac</name><name sortKey="Manohar, Monali" sort="Manohar, Monali" uniqKey="Manohar M" first="Monali" last="Manohar">Monali Manohar</name><name sortKey="Manohar, Monali" sort="Manohar, Monali" uniqKey="Manohar M" first="Monali" last="Manohar">Monali Manohar</name><name sortKey="Nadeau, Kari C" sort="Nadeau, Kari C" uniqKey="Nadeau K" first="Kari C" last="Nadeau">Kari C. Nadeau</name><name sortKey="Nadeau, Kari C" sort="Nadeau, Kari C" uniqKey="Nadeau K" first="Kari C" last="Nadeau">Kari C. Nadeau</name><name sortKey="Najeeb, Javaria" sort="Najeeb, Javaria" uniqKey="Najeeb J" first="Javaria" last="Najeeb">Javaria Najeeb</name><name sortKey="Narasimhan, Balasubramanian" sort="Narasimhan, Balasubramanian" uniqKey="Narasimhan B" first="Balasubramanian" last="Narasimhan">Balasubramanian Narasimhan</name><name sortKey="Narasimhan, Balasubramanian" sort="Narasimhan, Balasubramanian" uniqKey="Narasimhan B" first="Balasubramanian" last="Narasimhan">Balasubramanian Narasimhan</name><name sortKey="Otrelo Cardoso, Ana R" sort="Otrelo Cardoso, Ana R" uniqKey="Otrelo Cardoso A" first="Ana R" last="Otrelo-Cardoso">Ana R. Otrelo-Cardoso</name><name sortKey="Pham, Tho D" sort="Pham, Tho D" uniqKey="Pham T" first="Tho D" last="Pham">Tho D. Pham</name><name sortKey="Pham, Tho D" sort="Pham, Tho D" uniqKey="Pham T" first="Tho D" last="Pham">Tho D. Pham</name><name sortKey="Pinsky, Benjamin A" sort="Pinsky, Benjamin A" uniqKey="Pinsky B" first="Benjamin A" last="Pinsky">Benjamin A. Pinsky</name><name sortKey="Pinsky, Benjamin A" sort="Pinsky, Benjamin A" uniqKey="Pinsky B" first="Benjamin A" last="Pinsky">Benjamin A. Pinsky</name><name sortKey="Powell, Abigail E" sort="Powell, Abigail E" uniqKey="Powell A" first="Abigail E" last="Powell">Abigail E. Powell</name><name sortKey="Rogers, Angela J" sort="Rogers, Angela J" uniqKey="Rogers A" first="Angela J" last="Rogers">Angela J. Rogers</name><name sortKey="Rustagi, Arjun" sort="Rustagi, Arjun" uniqKey="Rustagi A" first="Arjun" last="Rustagi">Arjun Rustagi</name><name sortKey="Sahoo, Malaya K" sort="Sahoo, Malaya K" uniqKey="Sahoo M" first="Malaya K" last="Sahoo">Malaya K. Sahoo</name><name sortKey="Shah, Nigam H" sort="Shah, Nigam H" uniqKey="Shah N" first="Nigam H" last="Shah">Nigam H. Shah</name><name sortKey="Stevens, Bryan A" sort="Stevens, Bryan A" uniqKey="Stevens B" first="Bryan A" last="Stevens">Bryan A. Stevens</name><name sortKey="Tibshirani, Robert" sort="Tibshirani, Robert" uniqKey="Tibshirani R" first="Robert" last="Tibshirani">Robert Tibshirani</name><name sortKey="Tibshirani, Robert" sort="Tibshirani, Robert" uniqKey="Tibshirani R" first="Robert" last="Tibshirani">Robert Tibshirani</name><name sortKey="Wang, Hannah" sort="Wang, Hannah" uniqKey="Wang H" first="Hannah" last="Wang">Hannah Wang</name><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name><name sortKey="Wirz, Oliver F" sort="Wirz, Oliver F" uniqKey="Wirz O" first="Oliver F" last="Wirz">Oliver F. Wirz</name><name sortKey="Yamamoto, Fumiko" sort="Yamamoto, Fumiko" uniqKey="Yamamoto F" first="Fumiko" last="Yamamoto">Fumiko Yamamoto</name><name sortKey="Zehnder, James L" sort="Zehnder, James L" uniqKey="Zehnder J" first="James L" last="Zehnder">James L. Zehnder</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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